Thrombin heavy chain Polyclonal Antibody, AbBy Fluor-647 Conjugated, BF647, Rabbit
Biozol Catalog Number:
BSS-BS-1914R-BF647
Supplier Catalog Number:
bs-1914R-BF647
Alternative Catalog Number:
BSS-BS-1914R-BF647-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
IF
Species Reactivity:
Human, Mouse, Rat
Conjugation:
BF647
Alternative Names:
coagulation factor II, prothrombin, F2, Cf-2, Cf2, FII, F 2, coagulation factor II thrombin, Coagulation factor II, Coagulation factor II precursor, F2, Factor II, Factor-II, Prothrombin, prothrombin B-chain, PT, serine protease, THRB, THRB_HUMAN, Thrombin, Thrombin heavy chain.
Thrombin is the final protease in the blood coagulation cascade and serves both pro- and anticoagulant functions through the cleavage of several targets. The ability of thrombin to specifically recognize a wide range of substrates derives from interactions which occur outside of the active site of thrombin. Thrombin possesses two anion binding exosites which mediate many of its interactions with cofactors and substrates, and although many structures of thrombin have been solved, few such interactions have been described in molecular detail. Glycosaminoglycan binding to exosite II of thrombin plays a major role in switching off the procoagulant functions of thrombin by mediating its irreversible inhibition by circulating serpins and by its binding to the endothelial cell surface receptor thrombomodulin.
