68 kDa TATA-binding protein-associated factor, AF15 RNA polymerase II, TATA box binding protein (TBP) associated factor, 68 kD, Npl3, RBP56, RBP56_HUMAN, RNA binding protein 56, RNA-binding protein 56, TAF, TAF(II)68, TAF15, TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, TAF15 RNA polymerase II, TATA box binding protein associated factor, TAF2N, TAFII68, TATA binding protein associated factor 2N, TATA-binding protein-associated factor 2N.
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
