B7-H4, B7h4, B7S1, B7x, BC032925, Immune costimulatory protein B7H4, MGC41287, PRO1291, T cell costimulatory molecule B7x, V set domain-containing T cell activation inhibitor 1, VCTN1, VTCN1_HUMAN.
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
