RANTES, CCL5, TCP228, Small Inducible Cytokine A5, CCL5, SISd, MGC17164, SCYA5, RANTES, D17S136E, SIS-delta, chemokine (C-C motif) ligand 5, regulated on activation normal T cell expressed and secreted, chemokine (C-C motif) ligand 5, T-cell-specific protein RANTES, C-C motif chemokine 5, EoCP, Eosinophil chemotactic cytokine, RANTES(3-68), RANTES(4-68), CCL5_HUMAN,
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
