VP16 tag Antibody, Biotin Conjugated, Rabbit, Polyclonal
Biozol Catalog Number:
BSS-BS-2111R-BIOTIN
Supplier Catalog Number:
bs-2111R-Biotin
Alternative Catalog Number:
BSS-BS-2111R-BIOTIN-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, IHC-Fr, IHC-P, WB
Species Reactivity:
All
Conjugation:
Biotin
Alternative Names:
VP16_HHV1F,UL48, Tegument protein VP16, Alpha trans-inducing protein, Alpha-TIF, ICP25, Vmw65
HSV evades the immune system through interference with MHC class I antigen presentation on the cell surface, by blocking TAP or the transporter associated with antigen processing induced by the secretion of ICP-47 by HSV. In the host cell, TAP transports digested viral antigen epitope peptides from the cytosol to the endoplasmic reticulum, allowing these epitopes to be combined with MHC class I molecules and presented on the surface of the cell. Viral epitope presentation with MHC class I is a requirement for activation of cytotoxic T-lymphocytes (CTLs), the major effectors of the cell-mediated immune response against virally-infected cells. ICP-47 prevents initiation of a CTL-response against HSV, allowing the virus to survive for a protracted period in the host.
