TIEG1, TGF-beta inducible early growth response gene 1, Transforming growth factor-beta-inducible early growth response protein 1, Krueppel-like factor 10, TIEG-1, EGR-alpha, KLF10, TIEG, GDNF-inducible factor, Transcription factor GIF, mGIF, KLF10_HUMAN.
KLF10 is a transcription factor that plays a role in the regulation of cell growth. It binds to the consensus sequence 5-GGTGTG-3. KLF10 plays a role in the response to TGFbeta (through the TGFbeta/Smad signalling pathway) and estrogen. In both cases, KLF10 induces or repressed gene transcription to enhance the TGFbeta/Smad signalling pathway, as well as other pathways, to regulate cell proliferation, differentiation and apoptosis. KLF10 has been shown to have a role in skeletal disease (osteopenia/osteoporosis), hypertrophic cardiomyopathy, and breast and prostate cancer.
