Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyers patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Subunit : Homodimer, disulfide-linked. Binds to RET.
