GASC 1 protein, GASC1 antibody Gene amplified in squamous cell carcinoma 1 protein, JHDM3C, JmjC domain containing histone demethylation protein 3C, Jumonji domain containing protein 2C, KDM4C_HUMAN.
Histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-4, H3 Lys-27 nor H4 Lys-20. Demethylates trimethylated H3 Lys-9 and H3 Lys-36 residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
