6 O methylguanine DNA methyltransferase, Agat, AGT, AI267024, EC 2.1.1.63, Methylated DNA protein cysteine methyltransferase, Methylguanine DNA methyltransferase, MGC107020, MGMT: O-6 methylguanine DNA methyltransferase, O 6 methylguanine DNA alkyltransferase, O 6 methylguanine DNA methyltransferase, O-6 methylguanine DNA alkyltransferase, O-6-methylguanine-DNA methyltransferase, O6 methylguanine DNA methyltransferase, MGMT_HUMAN.
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
