APG 5, APG 5L, APG5, APG5 autophagy 5 like, APG5 like, APG5-like, Apoptosis specific protein, Apoptosis-specific protein, ASP, ATG 5, ATG5, ATG5 autophagy related 5 homolog, Autophagy protein 5, hAPG5, Homolog of S Cerevisiae autophagy 5, ATG5_HUMAN.
Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
