phospho-LRP5 (Thr1492) Polyclonal Antibody, PE Conjugated, Rabbit

Product Overview

• Article Name: phospho-LRP5 (Thr1492) Polyclonal Antibody, PE Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-25114R-PE
• Supplier Catalog Number: bs-25114R-PE
• Alternative Catalog Number: BSS-BS-25114R-PE-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: IF
• Species Reactivity: Human
• Conjugation: PE

Product Description

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

Product Properties

• Clonality: Polyclonal
• Concentration: 1mg/ml
• NCBI: 4041
• UniProt: O75197
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated Synthesised phosphopeptide derived from human LRP5 around the phosphorylation site of Thr1492
• Target: phospho-LRP5 (Thr1492)

Application Notes

• Application Dilute: IF()