Lyn phospho Y508, Lyn phospho Tyr508, p-Lyn Tyr508, Hck 2, JTK 8, JTK8, ONCOGENE LYN, Tyrosine protein kinase LYN, V yes 1 Yamaguchi sarcoma viral related oncogene homolog, Yamaguchi sarcoma viral v yes 1 related oncogene homolog, AA407514, EC 2.7.10.2, FLJ26625, LYN_HUMAN.
Lyn (also known as p53/56 Lyn) is a membrane associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL2 and IL3.
