Phospho-NF2 (Ser518) Polyclonal Antibody, Cy7 Conjugated, Rabbit

Product Overview

• Article Name: Phospho-NF2 (Ser518) Polyclonal Antibody, Cy7 Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-3291R-CY7
• Supplier Catalog Number: bs-3291R-Cy7
• Alternative Catalog Number: BSS-BS-3291R-CY7-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: IF, WB
• Species Reactivity: Mouse, Rat
• Conjugation: Cy7
• Alternative Names: ACN, SCH, BANF, Merlin, Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin, NF2

Product Description

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 4771
• UniProt: P35240
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Ser518
• Target: Phospho-NF2 (Ser518)

Application Notes

• Application Dilute: WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)