Phospho-NEDD4-2 (Ser342) Polyclonal Antibody, Biotin Conjugated, Rabbit

Product Overview

• Article Name: Phospho-NEDD4-2 (Ser342) Polyclonal Antibody, Biotin Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-3299R-BIOTIN
• Supplier Catalog Number: bs-3299R-Biotin
• Alternative Catalog Number: BSS-BS-3299R-BIOTIN-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IHC-Fr, IHC-P
• Conjugation: Biotin
• Alternative Names: E3 ubiquitin protein ligase NEDD4 like protein, E3 ubiquitin-protein ligase NEDD4-like, E3 ubiquitin-protein ligase NEDD4-like protein, KIAA0439, NED4L_HUMAN, NEDD4 2, NEDD4 2c, NEDD4-2, NEDD4-2a, NEDD4.2, NEDD4b, NEDD4L, NEDD4La, NEDD4Lb, NEDD4Lc, NEDD4Ld, NEDD4Le, NEDD4Lf, NEDD4Lg, NEDD4Lh, NEDL3, Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase, Neural precursor cell expressed, developmentally down regulated 4 like, RSP5, Ubiquitin protein ligase Rsp5.

Product Description

E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 23327
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic phosphopeptide derived from human NEDD4L around the phosphorylation site of Ser342
• Target: Phospho-NEDD4-2 (Ser342)

Application Notes

• Application Dilute: ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500)