Shc1Tyr349, SHC1phospho Y349, p46, p52, p52 SHC, p52SHC, p66, p66 SHC, p66SHC, SH2 domain protein C1, SHC Src homology 2 domain containing transforming protein 1, SHC 1, SHC A, Shc, SHC transforming protein 1, SHC transforming protein, SHC1, SHCA, Src homology 2 domain containing transforming protein C1.
The SHC gene encodes for a signaling and transforming protein containing Src homology 2 and 3 (SH2 and SH3) domains. The SHC gene encodes 2 widely expressed overlapping proteins of 46 and 52 kD, both containing a C-terminal SH2 domain. Adjacent to the SH2 region is a glycine and proline rich region. These 2 proteins differ in their N terminals. SHC proteins are involved in mitogenic signal transduction and act by coupling growth factor receptors to the RAS signaling pathway. The protein encoded by the SHC1 gene is thought to act as an adaptor in many signal transduction pathways.
