TIF1 gamma Polyclonal Antibody, Cy7 Conjugated, Rabbit

Product Overview

• Article Name: TIF1 gamma Polyclonal Antibody, Cy7 Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-3582R-CY7
• Supplier Catalog Number: bs-3582R-Cy7
• Alternative Catalog Number: BSS-BS-3582R-CY7-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: FC, IF
• Species Reactivity: Mouse, Rat
• Conjugation: Cy7
• Alternative Names: ECTO, PTC7, RFG7, TF1G, TIF1G, TIFGAMMA, TIF1GAMMA, E3 ubiquitin-protein ligase TRIM33, Ectodermin homolog, RET-fused gene 7 protein, Protein Rfg7, Transcription intermediary factor 1-gamma, TIF1-gamma, Tripartite motif-containing protein 33, TRIM33, KIAA1113

Product Description

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 51592
• UniProt: Q9UPN9
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human TIF1 gamma
• Target: T1 gamma

Application Notes

• Application Dilute: FCM(1:20-100), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)