CD38 negative kinase 1, EC 2.7.10.2 antibody Kinase of embryonic stem cells, Kos 1, Kos1, MGC46193, Non receptor tyrosine protein kinase TNK 1, Non receptor tyrosine protein kinase TNK1, Tnk 1, Tyrosine kinase non receptor 1.
Tnk1 is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
