KEAP1 Polyclonal Antibody, RBITC Conjugated, Rabbit

Product Overview

• Article Name: KEAP1 Polyclonal Antibody, RBITC Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-3648R-RBITC
• Supplier Catalog Number: bs-3648R-RBITC
• Alternative Catalog Number: BSS-BS-3648R-RBITC-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: IF, WB
• Species Reactivity: Human, Mouse, Rat
• Conjugation: RBITC
• Alternative Names: INrf2, KLHL19, Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, KIAA0132

Product Description

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 9817
• UniProt: Q14145
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human KEAP1
• Target: KEAP1

Application Notes

• Application Dilute: WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)