FLASH Polyclonal Antibody, Unconjugated, Rabbit

Product Overview

• Article Name: FLASH Polyclonal Antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BSS-BS-3657R
• Supplier Catalog Number: bs-3657R
• Alternative Catalog Number: BSS-BS-3657R-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IF, IHC-Fr, IHC-P, WB
• Species Reactivity: Mouse
• Conjugation: Unconjugated
• Alternative Names: CASP 8 associated protein 2, CASP8 associated protein 2, CASP8AP2, Caspase 8 associated protein 2, CED 4, CED4, FLASH homolog, FLASH homolog RIP 25, FLASH homolog RIP25, FLICE associated huge, FLICE associated huge protein, FLICE-associated huge protein, RIP 25, RIP25, AA387232, D4Ertd659e, mKIAA1315, C8AP2_HUMAN, CASP8-associated protein 2, FLICE-associated huge protein, FLJ11208, KIAA1315, OTTMUSP00000005125, RP23-69G24.1.

Product Description

FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis.

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 9994
• Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human FLASH/CASP8AP2
• Target: FLASH

Application Notes

• Application Dilute: WB(1:300-5000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)