ADMP-1, ADAMTS-2, ADAMTS-4, A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, Aggrecanase-1, ADAMTS4, KIAA0688, UNQ769/PRO1563
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu-|-Ala-393 site.