Recombinant human OST-beta protein, N-GST, Unconjugated

Product Overview

• Article Name: Recombinant human OST-beta protein, N-GST, Unconjugated
• Biozol Catalog Number: BSS-BS-42194P
• Supplier Catalog Number: bs-42194P
• Alternative Catalog Number: BSS-BS-42194P-20,BSS-BS-42194P-100,BSS-BS-42194P-500
• Manufacturer: Bioss
• Category: Proteine/Peptide
• Species Reactivity: Other
• Conjugation: Unconjugated

Product Description

The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.

Product Properties

• Tag: N-GST
• NCBI: 123264
• UniProt: Q86UW2
• Buffer: 0.01M TBS(pH7.4)
• Source: Recombinant human OST-beta protein is expressed in E.coli with N-His. It contains the amino acid sequence of 57-128/128
• Expression System: E.coli
• Purity: > 90% as determined by SDS- PAGE