Recombinant human LC3B protein, N-His, Unconjugated
Catalog Number:
BSS-BS-42305P
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| Article Name: | Recombinant human LC3B protein, N-His, Unconjugated |
| Biozol Catalog Number: | BSS-BS-42305P |
| Supplier Catalog Number: | bs-42305P |
| Alternative Catalog Number: | BSS-BS-42305P-20,BSS-BS-42305P-100,BSS-BS-42305P-500 |
| Manufacturer: | Bioss |
| Category: | Proteine/Peptide |
| Species Reactivity: | Other |
| Conjugation: | Unconjugated |
| A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy. |
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