CXCR3_HUMAN, Interferon-inducible protein 10 receptor, IP-10 receptor, C-X-C chemokine receptor type 3, CD 183, CD183, CD183 antigen, G protein-coupled receptor 9, G Protein Coupled Receptor 9, Chemokine (C X C motif) receptor 3, Chemokine (C X C) receptor 3, C-X-C Chemokine receptor, CXC Motif Receptor 3, Chemokine CXC Motif Receptor 3, CKRL2, CKR L2, CKR-L2, GPR9, CXC-R3, CXCR-3, IP10 receptor.
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011].
