Recombinant human VIPR2 protein, N-Trx-His, Unconjugated
Catalog Number:
BSS-BS-42334P
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| Article Name: | Recombinant human VIPR2 protein, N-Trx-His, Unconjugated |
| Biozol Catalog Number: | BSS-BS-42334P |
| Supplier Catalog Number: | bs-42334P |
| Alternative Catalog Number: | BSS-BS-42334P-20,BSS-BS-42334P-100,BSS-BS-42334P-500 |
| Manufacturer: | Bioss |
| Category: | Proteine/Peptide |
| Species Reactivity: | Other |
| Conjugation: | Unconjugated |
| Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide belonging to the vasoactive intestinal polypeptide/glucagon/ secretin family. It is widely distributed in the body, and a variety of biological actions have been reported. Recent studies have shown that there is a family of PACAP receptors (PACAPRs), and two members of this family have been identified. Mouse PACAPR-3 is a protein of 437 amino acids that has 50% and 51% identity with rat PACAP type I and type II receptors, respectively. It binds to vasoactive intestinal polypeptide as well as PACAP-38 and -27, with a slightly higher affinity for PACAP-38, PACAPR-3 mRNA is expressed at high levels in MIN6, at moderate levels in pancreatic islets and other insulin-secreting cell lines, HIT-T15 and RINm5F, as well as in the lung, brain, stomach, and colon, and at low levels in the heart. PACAPR-3 participates in the regulation of insulin secretion. insulin secretion from MIN6 cells is significantly stimulated by PACAP-38. |
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