Recombinant human MLKL protein, GST & His, Unconjugated
Catalog Number:
BSS-BS-42465P
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| Article Name: | Recombinant human MLKL protein, GST & His, Unconjugated |
| Biozol Catalog Number: | BSS-BS-42465P |
| Supplier Catalog Number: | bs-42465P |
| Alternative Catalog Number: | BSS-BS-42465P-20,BSS-BS-42465P-100,BSS-BS-42465P-500 |
| Manufacturer: | Bioss |
| Category: | Proteine/Peptide |
| Species Reactivity: | Other |
| Conjugation: | Unconjugated |
| This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]. |
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