Clgi, Collagenase inhibitor, EPA, EPO, Erythroid Potentiating Activity, Fibroblast collagenase inhibitor, FLJ90373, HC, Human Collagenase Inhibitor, Metalloproteinase inhibitor 1, Metalloproteinase inhibitor 1 precursor, OTTHUMP00000023214, TIMP 1, TIMP, TIMP metallopeptidase inhibitor 1, TIMP1 protein, Tissue Inhibitor of Metalloproteinase 1, Tissue inhibitor of metalloproteinases, Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro, but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
