FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn a chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and -2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.
Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.
Source:
Recombinant mouse FCGRT&B2M Heterodimer protein is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 22-297/365&21-119/119
Expression System:
HEK293
Purity:
> 90% as determined by SDS- PAGE
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