Collagen IV Polyclonal Antibody, Unconjugated, Rabbit

Product Overview

• Article Name: Collagen IV Polyclonal Antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BSS-BS-4595R
• Supplier Catalog Number: bs-4595R
• Alternative Catalog Number: BSS-BS-4595R-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, FC, IF, IHC-Fr, IHC-P, WB
• Species Reactivity: Human
• Conjugation: Unconjugated
• Alternative Names: ICH, HANAC, POREN1, arresten, Collagen alpha-1(IV) chain, COL4A1

Product Description

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a chicken-wire meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 1282
• Pubmed: 28898253
• UniProt: P02462
• Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human Collagen alpha-1(IV) chain
• Target: Collagen IV

Application Notes

• Application Dilute: WB(1:300-5000), ELISA(1:500-1000), FCM(1:20-100), IHC-P(1:200-400), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)