Methyl-CpG-binding domain protein 2, MBD2, DMTase, Methyl-CpG-binding protein MBD2
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Source:
Polyclonal antibody raised in rabbit against mouse MBD2, using a KLH-conjugated synthetic peptide containing an amino acid sequence from the central part of the protein
Target:
MBD2
Application Dilute:
WB(1:300-5000), ELISA(1:500-1000)
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