phospho-CDKN1A/p21 (Thr57) Polyclonal Antibody, AbBy Fluor-488 Conjugated, BF488, Rabbit

Product Overview

• Article Name: phospho-CDKN1A/p21 (Thr57) Polyclonal Antibody, AbBy Fluor-488 Conjugated, BF488, Rabbit
• Biozol Catalog Number: BSS-BS-5238R-BF488
• Supplier Catalog Number: bs-5238R-BF488
• Alternative Catalog Number: BSS-BS-5238R-BF488-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: IF, WB
• Species Reactivity: Human, Mouse, Rat
• Conjugation: BF488
• Alternative Names: P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, CDKN1A, MDA6, PIC1

Product Description

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 1026
• UniProt: P38936
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic phosphopeptide derived from human CDKN1A around the phosphorylation site of Thr57 [TE(p-T)PL]
• Target: phospho-CDKN1A/p21 (Thr57)

Application Notes

• Application Dilute: WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)