RHOAphospho S188, RhoA protein, Aplysia ras related homolog 12, ARH 12, ARH12, ARHA, H 12, Oncogene RHO H12, Ras homolog gene family member A, RHO 12, Rho A, RHO H12, RHO12, RHOH 12, RHOH12, Small GTP binding protein Rho A, Small GTP binding protein RhoA, Transforming protein Rho A, Transforming protein RhoA.
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
