TRIM25phospho S100_EFP, Estrogen responsive finger protein, RNF 147, RNF147, TRI25, TRIM 25, Tripartite mot containing 25, Tripartite mot containing protein 25, Z147, Zinc finger protein 147, Zinc finger protein 147 estrogen responsive finger protein, ZNF 147, ZNF147.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc binding domains, a RING, a B box type 1 and a B box type 2, and a coiled coil region. The protein localizes to the cytoplasm. The presence of potential DNA binding and dimerization transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.
