KDM5-C70 --- JARID1 Histone Demethylases Inhibitor, CAS [[1596348-32-1]], Unconjugated

Product Overview

• Article Name: KDM5-C70 --- JARID1 Histone Demethylases Inhibitor, CAS [[1596348-32-1]], Unconjugated
• Biozol Catalog Number: BSS-BS-60192C
• Supplier Catalog Number: bs-60192C
• Alternative Catalog Number: BSS-BS-60192C-10,BSS-BS-60192C-2
• Manufacturer: Bioss
• Category: Biochemikalien
• Conjugation: Unconjugated

Product Description

KDM5-C70 is an ethyl ester derivative of KDM5-C49, which is a potent and selective inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases. The highly polar carboxylate group of KDM5-C49 restricts its cellular permeability, therefore KDM5-C70 was developed as a pro-drug, masking the polarity of the acid group of the KDM5-C49, for cellular assays and in vivo use. KDM5-C70 increases H3K4me3 levels in myeloma cells. Treatment of MCF7 and MDA-MB-231 breast cancer cells with KDM5-C70 significantly increased global levels of H3K4me3 while having little impact on H3K4me2/me1 or modifications regulated by other histone lysine demethylases.

Product Properties

• Buffer: Powder
• CAS Number: [1596348-32-1]