LLY-507 --- Protein-lysine Methyltransferase SMYD2 Inhibitor, CAS [[1793053-37-8]], Unconjugated
Biozol Catalog Number:
BSS-BS-60259C
Supplier Catalog Number:
bs-60259C
Alternative Catalog Number:
BSS-BS-60259C-10,BSS-BS-60259C-2
Manufacturer:
Bioss
Category:
Biochemikalien
Conjugation:
Unconjugated
LLY-507 is a potent, selective and cell permeable protein lysine methyltransferase SMYD2 inhibitor with IC50 <15 nM. It binds in the substrate peptide-binding pocket. It has >100-fold selectivity over other methyltransferases and other non-epigenetic targets. LLY-507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM. It inhibited the proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.
Buffer:
Powder
CAS Number:
[1793053-37-8]
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