GNF7156, beta Cell Proliferation Inducer, CAS [[2041071-54-7]], Unconjugated
Biozol Catalog Number:
BSS-BS-60293C
Supplier Catalog Number:
bs-60293C
Alternative Catalog Number:
BSS-BS-60293C-10,BSS-BS-60293C-2
Manufacturer:
Bioss
Category:
Biochemikalien
Conjugation:
Unconjugated
GNF7156 is a highly potent and selective small molecule that promotes pancreatic beta cell proliferation in rodent (EC50 ~2.2 µM)and human primary islets (EC50 ~0.76 µM). It acts most likely as a result of combined inhibition of DYRK1A and GSK3B. GNF7156-treated human islets retain functionality in vitro and after transplantation into diabetic mice. Oral dosing of GNF7156 in diabetic mice induces beta-cell proliferation, increases beta-cell mass and insulin content, and improves glycaemic control. Biochemical, genetic and cell biology data point to Dyrk1a as the key molecular target. GNF7156 is a good chemical tool to support the feasibility of treating diabetes with an oral therapy to restore beta-cell mass, and highlights a tractable pathway for future drug discovery efforts.
Buffer:
Powder
CAS Number:
[2041071-54-7]
* VAT and and shipping costs not included. Errors and price changes excepted
