DASA-58 (ML203), Pyruvate Kinase M2 (PKM2) Activator, CAS [[1203494-49-8]], Unconjugated

Product Overview

• Article Name: DASA-58 (ML203), Pyruvate Kinase M2 (PKM2) Activator, CAS [[1203494-49-8]], Unconjugated
• Biozol Catalog Number: BSS-BS-60305C
• Supplier Catalog Number: bs-60305C
• Alternative Catalog Number: BSS-BS-60305C-10,BSS-BS-60305C-2
• Manufacturer: Bioss
• Category: Biochemikalien
• Conjugation: Unconjugated

Product Description

DASA-58 (ML203) is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. DASA-58 inhibits LPS-induced Hif-1alpha and IL-1beta, as well as the expression of a range of other Hif-1alpha-dependent genes. In PC3 cells, DASA-58 impairs stromal-induced EMT program by restoring PK activity and abrogating the nuclear translocation of PKM2, as well as its association with HIF-1alpha. It also dramatically reduces (~6-fold) CAFs-induced lung metastases formation in PC3 cells.

Product Properties

• Buffer: Powder
• CAS Number: [1203494-49-8]