POU class 6 homeobox 2, POU domain class 6 transcription factor 2, Retina derived POU domain factor 1, RPF 1, RPF1, Wilms tumor suppressor locus, WT 5, WT5, WTSL, PO6F2_HUMAN.
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
