CRISTIN3, FLJ40906, hRspo1, R spondin homolog Xenopus laevis, R spondin homolog, R spondin1, R-spondin-1, Roof plate specic spondin, Roof plate-specic spondin-1, RP11-566C13.1, RSPO, Rspo1, RSPO1_HUMAN.
RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.