BLU-9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU-9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU-9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho beta (KLB) could potentially respond to treatment with an FGFR4 inhibitor.
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CAS Number:
[1538604-68-0]
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