GSK-2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). GSK-2981278 is a strong RORgamma-selective inverse agonist that inhibits activation of the il17 promoter. GSK-2981278 robustly inhibits RORgamma-mediated cytokine production at both the mRNA and protein level. GSK-2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK-2981278 will significantly limit Th17-type cytokine expression and should therefore lead to improved clinical outcomes for patients.
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Powder
CAS Number:
[1474110-21-8]
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