MRGPRC, G protein coupled receptor MRGX1, G protein coupled receptor SNSR3, GPCR, Mas related G protein coupled receptor member X1, MAS related gene MRGX1, MAS related GPR member X1, MRGPRX1, MRGX1, Sensory neuron specic G protein coupled receptor 3/4, Seven transmembrane helix receptor, SNSR3, SNSR4, MRGX1_HUMAN, MRGPRX3, MRGX3, MRGPRX4, MRGX4, SNSR5, SNSR6, SNSR1, SNSR2.
There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.
