NALP3/CIAS1 Polyclonal Antibody, PE Conjugated, Rabbit
Biozol Catalog Number:
BSS-BS-6655R-PE
Supplier Catalog Number:
bs-6655R-PE
Alternative Catalog Number:
BSS-BS-6655R-PE-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
IF, WB
Species Reactivity:
Canine, Human, Mouse, Rat
Conjugation:
PE
Alternative Names:
NACHT, LRR and PYD domains-containing protein 3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, NLRP3, C1orf7, CIAS1, NALP3, PYPAF1
May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
