JTK 1, JTK1, Non receptor tyrosine protein kinase 2, Non receptor tyrosine protein kinase TYK2, Non-receptor tyrosine-protein kinase TYK2, Protein Tyrosine Kinase 2, TYK 2, Tyk2, TYK2_HUMAN, Tyrosine kinase 2.
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].
