The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). Overexpression of the NR2B-subunit of the NMDA Receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression (Clayton et al., 2002a, Clayton et al., 2002b). Phosphorylation of Ser-1166 is thought to play an essential role in memory and neuronal development.
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Source:
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1166 of the NR2B subunit of the rat NMDA receptor, conjugated to keyhole limpet hemocyanin (KLH).
Purity:
Antigen Affinity purification from Pooled whole antiserum
Target:
NMDA NR2B Subunit (Ser1166)
Antibody Type:
Primary Antibody
Application Dilute:
WB(1:300-5000)
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