MHC class I Polyclonal Antibody, AbBy Fluor-647 Conjugated, BF647, Rabbit
Biozol Catalog Number:
BSS-BS-7335R-BF647
Supplier Catalog Number:
bs-7335R-BF647
Alternative Catalog Number:
BSS-BS-7335R-BF647-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
FC, WB
Species Reactivity:
Human
Conjugation:
BF647
Alternative Names:
MHC-1, MHC1, MHC 1, A 28, A 9, Aw 24, Aw 68, CLASS I HISTOCOMPATIBILITY ANTIGEN, H2 K1, H2K, HLA A, HLA class I histocompatibility antigen A 1 alpha chain, HLA class I histocompatibility antigen A 11 alpha chain, HLA class I histocompatibility antigen A 2 alpha chain, HLA class I histocompatibility antigen A 24 alpha chain, HLA class I histocompatibility antigen A 3 alpha chain, HLA class I histocompatibility antigen A 30 alpha chain, HLA class I histocompatibility antigen A 32 alpha chain, HLA class I histocompatibility antigen A 68 alpha chain, HLAA, Major histocompatibility complex class I A, MHC class I heavy chain H2 K.
MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.
