FLJ35621, FLJ37491, NAD dependent deacetylase sirtuin 2, NAD-dependent deacetylase sirtuin-2, Regulatory protein SIR2 homolog 2, Silencing information regulator 2 like, Silent information regulator 2, Silent mating type information regulation 2, Silent mating type information regulation 2 homolog, SIR 2, SIR2, SIR2 like, SIR2 like protein 2, Sir2 related protein type 2, SIR2-like protein 2, SIR2L, SIR2L2, SIRT 2, SIRT2, SIRT2_HUMAN, Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae), Sirtuin 2, Sirtuin type 2, Sirtuin2.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
