Insulin Receptor R Polyclonal Antibody, AbBy Fluor-647 Conjugated, BF647, Rabbit
Biozol Catalog Number:
BSS-BS-7531R-BF647
Supplier Catalog Number:
bs-7531R-BF647
Alternative Catalog Number:
BSS-BS-7531R-BF647-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
IF
Species Reactivity:
Human
Conjugation:
BF647
Alternative Names:
INSRR, Insulin receptor related receptor precursor, IR related receptor, IRR, Sirr, Insulin receptor-related protein, IR-related receptor, Insulin receptor-related protein beta chain, INSRR_HUMAN.
The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesn?t bind any of IR and IGF-1R known ligands. In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown.
