(R)-Roscovitine, CAS [[186692-46-6]], Unconjugated
Catalog Number:
BSS-BS-75342C
| Article Name: |
(R)-Roscovitine, CAS [[186692-46-6]], Unconjugated |
| Biozol Catalog Number: |
BSS-BS-75342C |
| Supplier Catalog Number: |
bs-75342C |
| Alternative Catalog Number: |
BSS-BS-75342C-1,BSS-BS-75342C-5,BSS-BS-75342C-50 |
| Manufacturer: |
Bioss |
| Category: |
Biochemikalien |
| Conjugation: |
Unconjugated |
| Potent and selective inhibitor of CDKs [1, 2, 4, 16]. More potent than olomoucine [3]. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM) [2], CDK2 (IC50 = 700 nM) [4] and CDK5/p35 (IC50 = 160 nM) [4,5]. Inhibits M phase promoting factor (MPF) kinase activity [2]. Arrests human fibroblasts in G1 phase [6]. Antitumor compound [8]. Activates the mitogen-activated protein kinase pathway [9]. Targets both the p53 and NF-kappaB pathways[10]. Has effects on calcium channel gating [12, 17, 18]. Prevents DNA damage-induced cyclin A1 upregulation [13]. Apoptosis inducer [11, 15, 20]. As CYC202 in phase I clinical trials [14]. Reviews [3, 7, 19]. |
| Buffer: |
Solid |
| CAS Number: |
[186692-46-6] |
