Chelerythrine chloride, CAS [[3895-92-9]], Unconjugated
Biozol Catalog Number:
BSS-BS-75392C
Supplier Catalog Number:
bs-75392C
Alternative Catalog Number:
BSS-BS-75392C-1,BSS-BS-75392C-5,BSS-BS-75392C-25
Manufacturer:
Bioss
Category:
Biochemikalien
Conjugation:
Unconjugated
Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase [1, 5]. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound [1, 2, 9, 12, 15]. Apoptosis inducer in cancer cells in vitro and in vivo [3, 9]. Activates MAPK and JUNK signaling pathways [4, 8]. Affects translocation of PKC from cytosol to plasma membrane [6]. Neurite outgrowth stimulator [7]. Inhibits binding of BclXL to Bak (IC50 = 1.5 µM) or Bad proteins and stimulates apoptosis in several cancer cell lines [10, 13]. Blocks human P2X7 receptor [11]. Induces cell cycle arrest in G1 phase [14]. Specific cyclooxygenase-2 inhibitor [15].
Buffer:
Solid
CAS Number:
[3895-92-9]
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