Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription [1]. Sonic hedgehog (Shh) signaling pathway inhibitor, downstream of SMO and SUFU [1]. Displays antiproliferative and antitumor activity in vitro and in vivo [1, 2 , 3, 4, 5]. Apoptosis inducer [1, 2 , 3, 4, 5].
Buffer:
Solid
CAS Number:
[500579-04-4]
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